Dublin, Jan. 23, 2026 (GLOBE NEWSWIRE) — The “High Content Screening Market – Global Industry Size, Share, Trends, Opportunity, and Forecast, 2021-2031” has been added to ResearchAndMarkets.com’s offering.
The Global High Content Screening Market is projected to expand from USD 1.28 Billion in 2025 to USD 2.02 Billion by 2031, achieving a CAGR of 7.89%
High Content Screening (HCS) combines automated microscopy with sophisticated image analysis to quantify phenotypic variations in cellular models, facilitating the simultaneous assessment of numerous biological parameters. This analytical capacity is crucial for detecting viable drug candidates and defining toxicity profiles during the early stages of development. The market is primarily propelled by the necessity to lower high attrition rates in drug discovery and the demand for assays that are more predictive and physiologically relevant. This momentum is underpinned by significant industry spending on innovation; for instance, the European Federation of Pharmaceutical Industries and Associations reported that the pharmaceutical sector invested €55 billion in research and development across Europe in 2024.
Despite these powerful growth drivers, the market encounters a major obstacle related to the complexity of data management and analysis. The production of terabytes of high-resolution image data during each screen creates a bottleneck, as the infrastructure and specialized bioinformatics expertise needed to process and store this information are resource-heavy. This technical difficulty raises the total cost of ownership and threatens to hinder the adoption of high content technologies within smaller laboratories and research institutions.
Market Drivers
Increasing investments in pharmaceutical and biotechnology R&D act as the primary catalyst for the Global High Content Screening Market. Faced with patent expirations, companies are directing capital toward early-stage discovery infrastructure to replenish their pipelines, funding the acquisition of automated microscopy platforms essential for high-throughput assays. This trend is highlighted by Novartis’s April 2025 press release, ‘Novartis to Expand US-Based R&D and Manufacturing,’ which announced a strategic commitment of $23 billion over five years to enhance research capabilities, underscoring the sector’s reliance on advanced screening for the efficient identification of therapeutic candidates.
The adoption of these technologies is further accelerated by the integration of artificial intelligence and machine learning, which address critical bottlenecks in image data analysis. Modern screening systems produce massive datasets that traditional methods cannot process at scale; consequently, AI algorithms have become indispensable for rapid phenotypic profiling.
This technological convergence is attracting significant capital aimed at digitizing drug discovery. For example, Isomorphic Labs announced in a March 2025 press release, ‘Isomorphic Labs announces $600 million funding,’ that it had secured $600 million to expand its AI engine for designing novel therapeutics. The impact of these tools is evident in regulatory productivity; the U.S. Food and Drug Administration’s Center for Drug Evaluation and Research reported in 2025 that 50 novel drugs were approved in the preceding year, demonstrating the successful translation of screened compounds.
Market Challenges
The Global High Content Screening Market confronts a significant hurdle regarding the complexity of data management and analysis. Since screening platforms generate terabytes of high-resolution imagery, the immense volume of information creates an operational bottleneck that necessitates extensive storage infrastructure and specialized bioinformatics expertise. This requirement drastically inflates the total cost of ownership, rendering the technology financially impractical for smaller laboratories and research institutions with limited capital. Consequently, the high resource intensity needed to process these datasets restricts the broader adoption of high-content technologies, directly limiting market expansion in cost-sensitive sectors.
This technical barrier is emphasized by widespread industry difficulties in handling complex biological data. According to the Pistoia Alliance, in 2024, 52% of life science professionals identified low-quality and poorly curated datasets as the main obstacle to implementing advanced analytical technologies. This statistic illustrates the magnitude of the data challenge, as organizations struggle to maintain the digital environment necessary for effective screening. When potential users cannot overcome these data processing obstacles, they are forced to forego high-content methods, thereby slowing the overall growth trajectory of the market.
Market Trends
The rise of microfluidic organ-on-chip screening technologies marks a pivotal shift toward physiologically relevant assays that mimic human tissue architecture more effectively than traditional 2D cultures. This trend is fundamentally driven by the industry’s urgent need to replace animal models with human-centric systems that can accurately predict drug toxicity and efficacy earlier in the pipeline. Regulatory bodies are actively catalyzing this transition, acknowledging that microphysiological systems offer superior predictive validity for safety assessments. According to the U.S. Food and Drug Administration’s April 2025 press release, ‘FDA Announces Plan to Phase Out Animal Testing Requirement for Monoclonal Antibodies and Other Drugs,’ the agency formally introduced a roadmap to replace animal testing with human-relevant methods, specifically promoting the use of organ-on-a-chip systems to improve drug safety and reduce R&D costs.
Simultaneously, the incorporation of CRISPR-Cas9 gene editing into high content assays is revolutionizing functional genomics by enabling the unbiased, large-scale interrogation of gene function. By combining precise genetic perturbations with phenotypic imaging, researchers can now directly link specific genetic alterations to cellular phenotypes, facilitating robust target identification and validation. This approach moves beyond simple compound screening to provide a deep mechanistic understanding of disease pathways at a scale previously unattainable. As noted by MIT News in July 2025 in the article ‘Scientists apply optical pooled CRISPR screening to identify potential new Ebola drug targets,’ researchers successfully utilized high-content imaging to screen approximately 40 million CRISPR-perturbed human cells, identifying hundreds of host proteins that alter viral infection levels.
Key Players Profiled in the High Content Screening Market:
- Danaher Corporation
- Perkinelmer Inc.
- Thermo Fisher Scientific Inc.
- Becton, Dickinson and Company
- Agilent Technologies, Inc.
- Bio-Rad Laboratories Inc.
- Yokogawa Electric Corporation
- Merck KGaA
- Tecan Group Ltd.
- BioTek Instruments, Inc.
Report Scope: In this report, the Global High Content Screening Market has been segmented into the following categories:
High Content Screening Market, by Product:
- Instruments
- Consumables
- Software
- Services
High Content Screening Market, by Application:
- Primary and Secondary Screening
- Target Identification & Validation
- Toxicity Studies
- Compound Profiling
- Others
High Content Screening Market, by End User:
- Pharmaceutical and Biotechnology Companies
- Academic and Government Institutions
- Contract Research Organization
High Content Screening Market, by Region:
- North America
- Europe
- Asia-Pacific
- South America
- Middle East & Africa
Key Attributes:
| Report Attribute | Details |
| No. of Pages | 180 |
| Forecast Period | 2025 – 2031 |
| Estimated Market Value (USD) in 2025 | $1.28 Billion |
| Forecasted Market Value (USD) by 2031 | $2.02 Billion |
| Compound Annual Growth Rate | 7.8% |
| Regions Covered | Global |
For more information about this report visit https://www.researchandmarkets.com/r/gwttzs
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- High Content Screening Market
